Состав:
Применение:
Применяется при лечении:
Страница осмотрена фармацевтом Милитян Инессой Месроповной Последнее обновление 2022-03-28
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Топ 20 лекарств с такими-же компонентами:
Топ 20 лекарств с таким-же применением:
Название медикамента
Предоставленная в разделе Название медикамента Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Mupiderm
Состав
Предоставленная в разделе Состав Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Mupirocin Calcium
Терапевтические показания
Предоставленная в разделе Терапевтические показания Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Мазь интраназальная: носительство стафилококков (в т.ч. штаммов Staphylococcus aureus полирезистентных и устойчивых к метициллину).
Мазь дерматологическая: лечение первичных инфекций кожных покровов — импетиго, фолликулит, фурункулез (в т.ч. фурункул наружного слухового прохода и ушной раковины), эктима; вторичных инфекций кожных покровов — инфицированная экзема, инфицированные травмы (ссадины, укусы насекомых), незначительные (не требующие госпитализации) раны и ожоги; профилактика раневой инфекции после небольших порезов, ран и мелких ссадин.
Способ применения и дозы
Предоставленная в разделе Способ применения и дозы Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Интраназально, наружно. Мазь интраназальная: наносят на внутреннюю поверхность ноздрей 2–3 раза в сутки в течение 5–7 дней.
Мазь для наружного применения: взрослым, детям и пациентам пожилого возраста небольшое количество наносят на пораженный участок кожи 2–3 раза в сутки, при необходимости накладывают асептическую повязку, курс лечения — до 10 дней.
При печеночной недостаточности применяется стандартная дозировка.
Почечная недостаточность — см. «Меры предосторожности».
Нельзя сочетать мазь Mupiderm с другими препаратами из-за риска ее разведения, снижения антибактериальной активности и стабильности.
Противопоказания
Предоставленная в разделе Противопоказания Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Гиперчувствительность к любому компоненту мази.
С осторожностью: при беременности и в период грудного вскармливания.
Побочные эффекты
Предоставленная в разделе Побочные эффекты Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Очень редко — зуд, жжение, саднение и сухость кожи в месте аппликации; редко — кожные аллергические реакции; в единичных случаях — системные аллергические реакции; ринит (при применении интраназальной мази).
Передозировка
Предоставленная в разделе Передозировка Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Данные отсутствуют.
Фармакодинамика
Предоставленная в разделе Фармакодинамика Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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В минимальных ингибирующих концентрациях обладает бактериостатическими, а в более высоких концентрациях — бактерицидными свойствами. Спектр антибактериальной активности in vitro:
— грамположительные аэробы: Staphylococcus aureus (в т.ч. штаммы, устойчивые к метициллину, и продуцирующие бета- лактамазы), Staphylococcus epidermidis и другие коагулазонегативные Staphylococcus spp., Streptococcus spp. ;
— грамотрицательные анаэробы: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Branhamella catarrhalis, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Bordetella pertussis;
— нечувствительные: Corynebacterium spp., виды семейства Enterobacteriaceae, грамотрицательные неферментирующие палочки, Micrococcus, анаэробы.
Фармакокинетика
Предоставленная в разделе Фармакокинетика Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Характеризуется плохой проницаемостью через неповрежденные кожные покровы. В случае всасывания через поврежденную кожу метаболизируется до микробиологически неактивной мониевой кислоты и быстро выводится почками.
Фармокологическая группа
Предоставленная в разделе Фармокологическая группа Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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- Другие антибиотики
Взаимодействие
Предоставленная в разделе Взаимодействие Mupidermинформация составлена на основе данных о другом лекарстве с точно таким же составом как лекарство Mupiderm. Будьте
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Сообщения отсутствуют.
Источники:
- https://www.drugs.com/search.php?searchterm=mupiderm
- https://pubmed.ncbi.nlm.nih.gov/?term=mupiderm
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Содержание
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Структурная формула
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Русское название
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Английское название
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Латинское название
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Химическое название
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Брутто формула
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Фармакологическая группа вещества Мупироцин
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Нозологическая классификация
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Код CAS
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Фармакологическое действие
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Характеристика
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Фармакология
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Применение вещества Мупироцин
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Противопоказания
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Ограничения к применению
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Применение при беременности и кормлении грудью
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Побочные действия вещества Мупироцин
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Способ применения и дозы
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Меры предосторожности
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Торговые названия с действующим веществом Мупироцин
Структурная формула
Русское название
Мупироцин
Английское название
Mupirocin
Латинское название
Mupirocinum (род. Mupirocini)
Химическое название
[2S-[2альфа(Е),3бета,4бета,5альфа [2R*,3R*(1R*,2R*)]]]-9-[[3-Метил-1-оксо-4-[тетрагидро-3,4-дигидрокси-5-[[3-(2-гидрокси-1-метилпропил)оксиранил]метил]-2H-пиран-2-ил]-2-бутенил]окси]нонановая кислота
Брутто формула
C26H44O9
Фармакологическая группа вещества Мупироцин
Нозологическая классификация
Список кодов МКБ-10
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J00 Острый назофарингит [насморк]
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J31.0 Хронический ринит
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L01 Импетиго
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L02 Абсцесс кожи, фурункул и карбункул
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L08.8 Другие уточненные местные инфекции кожи и подкожной клетчатки
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L08.9 Местная инфекция кожи и подкожной клетчатки неуточненная
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L30.3 Инфекционный дерматит
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L73.8.1* Фолликулит
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T14.0 Поверхностная травма неуточненной области тела
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T14.1 Открытая рана неуточненной области тела
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T30 Термические и химические ожоги неуточненной локализации
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W57 Укус или ужаливание неядовитым насекомым и другими неядовитыми членистоногими
Код CAS
12650-69-0
Фармакологическое действие
—
антибактериальное широкого спектра, бактериостатическое.
Характеристика
Антибиотик, получаемый в процессе ферментации Pseudomonas fluorescens.
Фармакология
Ингибирует синтез бактериальных белков путем обратимого и специфического связывания с изолейцин транспортной РНК-синтетазой. Абсорбция после накожной аппликации крайне мала. Всосавшаяся часть быстро метаболизируется в неактивную мониевую кислоту и экскретируется почками. Активен в отношении грамположительных аэробных микроорганизмов, включая Staphylococcus aureus (в т.ч. штаммы, устойчивые к метициллину), Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus pyogenes (в т.ч. коагулазонегативные). Действует также на грамотрицательные микроорганизмы (в т.ч. Escherichia coli, Haemophilus influenzae). Не обладает перекрестной устойчивостью с хлорамфениколом, эритромицином, фузидиевой кислотой, гентамицином, линкомицином, метициллином, неомицином, стрептомицином, тетрациклином.
Применение вещества Мупироцин
Наружно: первичные инфекции кожи — импетиго, фолликулит, фурункулез (в т.ч. фурункулы наружного слухового прохода и ушной раковины), эктима; вторичные инфекции кожи — инфицированная экзема, инфицированные травмы (ссадины, укусы насекомых), незначительные (не требующие госпитализации) раны и ожоги; профилактика бактериального инфицирования небольших ран, порезов и других «чистых» повреждений кожи.
Интраназально: местные инфекции носовой полости, вызванные чувствительными к мупироцину микроорганизмами, включая носительство Staphylococcus aureus (в т.ч. метициллин-резистентные штаммы).
Противопоказания
Гиперчувствительность.
Ограничения к применению
Беременность, кормление грудью.
Применение при беременности и кормлении грудью
Категория действия на плод по FDA — B.
Побочные действия вещества Мупироцин
Жжение, зуд в месте аппликации, аллергические реакции.
Способ применения и дозы
Наружно, интраназально. Наносят на пораженный участок до 3 раз в сутки в течение 10 дней. Мазь назальная вводится в передние носовые ходы 2–3 раза в сутки в течение недели.
Меры предосторожности
Полиэтиленгликоль, входящий в состав мази для накожного нанесения, может адсорбироваться через поврежденную кожу, и поскольку он выводится почками, ее следует с осторожностью применять при наличии тяжелой почечной недостаточности. Мазь назальную нельзя применять в офтальмологии.
Торговые названия с действующим веществом Мупироцин
| Торговое название | Цена за упаковку, руб. |
|---|---|
| Бактробан® |
от 998.00 до 998.00 |
| Бондерм® |
от 566.00 до 571.00 |
| Супироцин® |
от 630.00 до 729.00 |
Components:
Method of action:
Treatment option:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 2022-04-05
Attention!
Information on this page is intended only for medical professionals!
Information is collected in open sources and may contain significant errors!
Be careful and double-check all the information on this page!
Top 20 medicines with the same components:
Top 20 medicines with the same treatments:
The information provided in of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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Mupiderm 2%
Qualitative and quantitative composition
The information provided in Qualitative and quantitative composition of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Qualitative and quantitative composition in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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Mupirocin Calcium
Therapeutic indications
The information provided in Therapeutic indications of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Mupiderm 2% Cream is indicated for the topical treatment of secondarily infected traumatic lesions such as small lacerations, sutured wounds or abrasions (up to 10 cm in length or 100 cm2 in area), due to susceptible strains of Staphylococcus aureus and Streptococcus pyogenes.
The elimination of nasal carriage of staphylococci, including methicillin resistant Staphylococcus aureus (MRSA).
Dosage (Posology) and method of administration
The information provided in Dosage (Posology) and method of administration of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Dosage
Adults/children > 1 year/elderly
3 times a day for up to 10 days, depending on the response.
Patients not showing a clinical response within 3 to 5 days should be re-evaluated.
The duration of treatment should not exceed 10 days.
Children < 1 year
Mupiderm 2% Cream has not been studied in infants under 1 year old and therefore it should not be used in these patients until further data become available.
Patients with hepatic impairment: No dosage adjustment is necessary.
Patients with renal impairment: No dosage adjustment is necessary.
Method of administration
A thin layer of cream should be applied to the affected area with a piece of clean cotton wool or gauze swab.
The treated area may be covered by a dressing.
Do not mix with other preparations, as there is a risk of dilution, resulting in a reduction in the antibacterial activity and potential loss of stability of the mupirocin in the cream.
Posology
Adults (including the elderly) and children:
Mupiderm 2% should be applied to the anterior nares two to three times a day as follows:
A small amount of the ointment about the size of a match head is placed on the little finger and applied to the inside of each nostril. The nostrils are closed by pressing the sides of the nose together; this will spread the ointment throughout the nares. A cotton bud may be used instead of the little finger for the application in particular to infants or patients who are very ill.
Nasal carriage should normally clear within 5-7 days of commencing treatment.
Method of administration
Topical.
Contraindications
The information provided in Contraindications of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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Hypersensitivity to mupirocin or any of the excipients.
Special warnings and precautions for use
The information provided in Special warnings and precautions for use of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Should a possible sensitisation reaction or severe local irritation occur with the use of Mupiderm 2% Cream, treatment should be discontinued, the product should be washed off and appropriate therapy instituted.
As with other antibacterial products, prolonged use may result in overgrowth of non-susceptible organisms.
Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening. Therefore, it is important to consider its diagnosis in patients who develop diarrhoea during or after antibiotic use. Although this is less likely to occur with topically applied mupirocin, if prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patient investigated further.
Mupiderm 2% Cream formulation is not suitable for ophthalmic use and intranasal use.
Avoid contact with the eyes. If contaminated, the eyes should be thoroughly irrigated with water until the cream residues have been removed.
Mupiderm 2% Cream contains cetyl alcohol and stearyl alcohol. These inactive ingredients may cause local skin reactions (e.g. contact dermatitis).
Should a possible sensitisation reaction or severe local irritation occur with the use of Mupiderm 2%, treatment should be discontinued, the product should be wiped away and appropriate therapy instituted.
As with other antibacterial products, prolonged use may result in overgrowth of non-susceptible organisms.
Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening. Therefore, it is important to consider its diagnosis in patients who develop diarrhoea during or after antibiotic use. Although this is less likely to occur with topically applied mupirocin, if prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patient investigated further.
This mupirocin nasal ointment formulation is not suitable for ophthalmic use.
Avoid contact with the eyes. If contaminated, the eyes should be thoroughly irrigated with water until the ointment residues have been removed.
Effects on ability to drive and use machines
The information provided in Effects on ability to drive and use machines of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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No adverse effects on the ability to drive or operate machinery have been identified.
Undesirable effects
The information provided in Undesirable effects of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
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Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Data from clinical trials was used to determine the frequency of very common to rare undesirable effects. Very rare adverse reactions were primarily determined from post-marketing experience data and therefore refer to reporting rate rather than true frequency.
The following convention has been used for the classification of frequency:-
very common >1/10, common >1/100 and <1/10 , uncommon >1/1000 and <1/100, rare >1/10,000 and <1/1000 , very rare <1/10,000.
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Immune system disorders: |
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Very rare: |
Systemic allergic reactions including anaphylaxis, generalised rash, urticaria and angioedema |
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Skin and subcutaneous tissue disorders: |
|
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Common: |
Application site hypersensitivity reactions including urticaria, pruritus, erythema, burning sensation, contact dermatitis, rash |
Skin dryness and erythema have been reported in irritancy studies in volunteers.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk.yellowcard
Adverse reactions are listed below by system organ class and frequency. Frequencies are defined as: very common (>1/10), common (>1/100, <1/10), uncommon (>1/1000, <1/100), rare (>1/10,000, <1/1000), very rare (<1/10,000), including isolated reports.
Uncommon adverse reactions were determined from pooled safety data from a clinical trial population of 422 treated patients encompassing 12 clinical studies. Very rare adverse reactions were primarily determined from post-marketing experience data and therefore refer to reporting rate rather than true frequency.
|
Immune system disorders |
|
|
Very rare: |
Cutaneous hypersensitivity reactions. Systemic allergic reactions including anaphylaxis, generalised rash, urticaria and angioedema. |
|
Respiratory, thoracic and mediastinal disorders |
|
|
Uncommon: |
Nasal mucosa reactions. |
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
Overdose
The information provided in Overdose of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
more…
Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Symptoms:
There is currently limited experience with overdosage of Mupiderm 2% Cream.
Management:
There is no specific treatment for an overdose of Mupiderm 2% Cream. In the event of overdose, the patient should be treated supportively with appropriate monitoring as necessary. Further management should be as clinically indicated or as recommended by the national poisons centre, where available.
Symptoms and signs
There is currently limited experience with overdosage of mupirocin.
Treatment
There is no specific treatment for an overdose of mupirocin. In the event of overdose, the patient should be treated supportively with appropriate monitoring as necessary. Further management should be as clinically indicated or as recommended by the national poisons centre, where available.
Pharmacodynamic properties
The information provided in Pharmacodynamic properties of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
more…
Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Pharmacotherapeutic group: Dermatologicals ATC code: D06AX09, Antibiotics and chemotherapeutics for dermatological use
Mode of Action
Mupirocin is a novel antibiotic produced through fermentation by Pseudomonas fluorescens. Mupirocin inhibits isoleucyl transfer-RNA synthetase, thereby arresting bacterial protein synthesis.
Mupirocin has bacteriostatic properties at minimum inhibitory concentrations and bactericidal properties at the higher concentrations reached when applied locally.
Mechanism of Resistance
Low-level resistance in staphylococci is thought to result from point mutations within the usual staphylococcal chromosomal gene (ileS) for the target isoleucyl tRNA synthetase enzyme. High-level resistance in staphylococci has been shown to be due to a distinct, plasmid encoded isoleucyl tRNA synthetase enzyme.
Intrinsic resistance in Gram negative organisms such as the Enterobacteriaceae could be due to poor penetration of the outer membrane of the Gram-negative bacterial cell wall.
Due to its particular mode of action, and its unique chemical structure, mupirocin does not show any cross-resistance with other clinically available antibiotics.
Microbiological Susceptibility
The prevalence of acquired resistance may vary geographically and with time for selected species, and local information on resistance is desirable, particularly when treating severe infections. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infection is questionable.
|
Commonly susceptible species |
|
Staphylococcus aureus* |
|
Streptococcus pyogenes* |
|
Streptococcus spp. (β-haemolytic, other than S. pyogenes) |
|
Species for which acquired resistance may be a problem |
|
Staphylococcus spp., coagulase negative |
|
Inherently resistant organisms |
|
Corynebacterium spp. |
|
Micrococcus spp. |
* Activity has been satisfactorily demonstrated in clinical studies
Pharmacotherapeutic group: Antibiotics and chemotherapeutics for dermatological use.
ATC code: D06AX09
Mode of Action
Mupirocin is a novel antibiotic produced through fermentation by Pseudomonas fluorescens. Mupirocin inhibits isoleucyl transfer-RNA synthetase, thereby arresting bacterial protein synthesis.
Mupirocin has bacteriostatic properties at minimum inhibitory concentrations and bactericidal properties at the higher concentrations reached when applied locally.
Mechanism of Resistance
Low-level resistance in staphylococci is thought to result from point mutations within the usual staphylococcal chromosomal gene (ileS) for the target isoleucyl tRNA synthetase enzyme. High-level resistance in staphylococci has been shown to be due to a distinct, plasmid encoded isoleucyl tRNA synthetase enzyme.
Intrinsic resistance in Gram negative organisms such as the Enterobacteriaceae could be due to poor penetration of the outer membrane of the Gram-negative bacterial cell wall.
Due to its particular mode of action, and its unique chemical structure, mupirocin does not show any cross-resistance with other clinically available antibiotics.
Microbiological Susceptibility
The prevalence of acquired resistance may vary geographically and with time for selected species, and local information on resistance is desirable, particularly when treating severe infections. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infection is questionable.
|
Commonly susceptible species: |
|
Staphylococcus aureus* |
|
Streptococcus spp. |
|
Species for which acquired resistance may be a problem: |
|
Methicillin-Resistant-Staphylococcus aureus (MRSA) |
|
Methicillin-resistant coagulase-negative Staphylococci (MRCoNS) |
|
Inherently resistant organisms: |
|
Corynebacterium spp. |
|
Micrococcus spp. |
*Clinical efficacy has been demonstrated for susceptible isolates in approved clinical indications.
Mupirocin susceptibility (MIC) breakpoints for Staphylococcus aureus:
Susceptible: less than or equal to 1mg/L
Resistant: greater than 256 mg/L
Pharmacokinetic properties
The information provided in Pharmacokinetic properties of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
more…
Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Absorption
Systemic absorption of mupirocin through intact human skin is low although it may occur through broken/diseased skin. However, clinical trials have shown that when given systemically, it is metabolised to the microbiologically inactive metabolite monic acid and rapidly excreted.
Excretion
Mupirocin is rapidly eliminated from the body by metabolism to its inactive metabolite monic acid which is rapidly excreted by the kidney.
Studies have shown that following topical application of mupirocin there is very little systemic absorption of drug-related material. To mimic possible enhanced systemic penetration of mupirocin by application to damaged skin or a vascular site such as the mucous membrane, intravenous studies have been performed. Mupirocin was rapidly eliminated from the plasma by metabolism to monic acid, which in turn was excreted mainly in the urine.
Pharmacotherapeutic group
The information provided in Pharmacotherapeutic group of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
more…
Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Dermatologicals ATC code: D06AX09, Antibiotics and chemotherapeutics for dermatological use
Antibiotics and chemotherapeutics for dermatological use.
Preclinical safety data
The information provided in Preclinical safety data of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
more…
Pre-clinical effects were seen only at exposures which are extremely unlikely to cause concern for humans under normal conditions of clinical use. Mutagenicity studies revealed no risks to man.
Incompatibilities
The information provided in Incompatibilities of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
more…
Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Special precautions for disposal and other handling
The information provided in Special precautions for disposal and other handling of Mupiderm 2%
is based on data of another medicine with exactly the same composition as the Mupiderm 2%.
. Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Mupiderm 2% directly from the package or from the pharmacist at the pharmacy.
more…
Cream; Nasal ointment; Ointment; Ointment for external use; Ointment nasal
Intranasal ointment
Any product remaining at the end of treatment should be discarded.
Wash your hands after application.
Any product remaining at the end of treatment should be discarded.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Wash your hands after application.
References:
- https://www.drugs.com/search.php?searchterm=mupiderm-2
- https://pubmed.ncbi.nlm.nih.gov/?term=mupiderm-2
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Find in a country:
Крем белого или почти белого цвета.
1 г крема содержит:
активное вещество: мометазона фуроат 0,001 г;
вспомогательные вещества: гексиленгликоль, глицерилмоностеарат 40-55, цетостеариловый спирт, макрогола 20 цетилстеарат, воск белый, титана диоксид, алюминия крахмала октенилсукцинат, кислота фосфорная разведенная, вода очищенная, вазелин белый.
глюкокортикостероид для местного применения.
Код АТХ
D07AC13
Фармакологическое действие
Фармакодинамика
Мометазон — синтетический глюкокортикостероид (ГКС), обладающий противовоспалительным, противозудным и антиэкссудативным действием. ГКС индуцируют выделение белков, ингибирующих фосфолипазу А2, и известных под общим названием липокортины, которые контролируют биосинтез таких медиаторов воспаления, как простагландины и лейкотриены, путем торможения высвобождения их общего предшественника, арахидоновой кислоты.
Фармакокинетика
Абсорбция крема Унидерм® незначительна. Через 8 часов после нанесения на неповрежденную кожу (без окклюзионной повязки) в системном кровотоке обнаруживается около 0,4% препарата.
Воспалительные явления и зуд при дерматозах, поддающихся глюкокортикостероидной терапии.
Повышенная чувствительность к какому-либо компоненту препарата или к глюкокортикостероидным средствам.
Розовые угри, периоральный дерматит.
Бактериальная, вирусная (Herpes simplex, ветряная оспа, Herpes zoster) или грибковая инфекция кожи.
Туберкулез, сифилис.
Поствакцинальные реакции.
Детский возраст до 6 месяцев.
Беременность (лечение обширных участков кожи, длительное лечение).
Период лактации (применение в больших дозах или/и в течение длительного времени). С осторожностью
Нанесение на кожу лица и в складки, применение окклюзионных повязок, а также лечение больших участков кожи и/или длительное лечение (особенно у детей). Применение во время беременности и лактации
Безопасность применения крема Унидерм® во время беременности и лактации не изучена.
Глюкокортикостероиды проникают через плацентарный барьер. Следует избегать длительного лечения и применения больших доз во время беременности в связи с угрозой негативного воздействия на развитие плода.
Глюкокортикостероиды выделяются с грудным молоком. В случае, когда предполагается применение ГКС в больших дозах и/или в течение длительного времени, следует прекратить грудное вскармливание. Способ применения и дозировка
Наружно.
Тонкий слой крема Унидерм® наносят на пораженные участки кожи один раз в день. Продолжительность курса лечения определяется его эффективностью, а также переносимостью пациентом, наличием и выраженностью побочных эффектов. Побочные явления
Редко — раздражение и сухость кожи, ощущение жжения, зуд, фолликулит, гипертрихоз, угревая сыпь, гипопигментация, периоральный дерматит, аллергический контактный дерматит, мацерация кожи, присоединение вторичной инфекции, признаки атрофии кожи, стрии, потница. Менее чем в 1% случаев — образование папул, пустул.
При применении крема Унидерм® в течение длительного времени и/или для лечения больших участков кожи, или с использованием окклюзионных повязок, особенно у детей и подростков, могут возникнуть побочные эффекты, характерные для ГКС системного действия, включая надпочечниковую недостаточность и синдром Кушинга.
Симптомы: угнетение функции гипоталамо-гипофизарно-надпочечниковой системы, включая вторичную надпочечниковую недостаточность.
Лечение: симптоматическое, при необходимости — коррекция электролитного дисбаланса, отмена препарата (при длительной терапии — постепенная отмена).
При нанесении на большие участки кожи в течение длительного времени, особенно при применении окклюзионных повязок, возможно развитие системного действия ГКС. Учитывая это, больные должны наблюдаться в отношении признаков подавления функции гипоталамо-гипофизарно-надпочечниковой системы и развития синдрома Кушинга.
Следует избегать попадания крема Унидерм® в глаза.
Пропиленгликоль, входящий в состав препарата, может вызывать раздражение в месте нанесения. В таких случаях следует прекратить применение крема Унидерм® и назначить соответствующее лечение.
Следует учитывать, что ГКС способны изменять проявления некоторых заболеваний кожи, что может затруднить постановку диагноза. Кроме того, применение ГКС может быть причиной задержки заживления ран.
При длительной терапии ГКС внезапное прекращение терапии может привести к развитию синдрома рикошета, проявляющегося в форме дерматита с интенсивным покраснением кожи и ощущением жжения. Поэтому после длительного курса лечения отмену препарата следует производить постепенно, например, переходя на интермиттирующую схему лечения перед тем, как его полностью прекратить.
Применение в педиатрии
Безопасность и эффективность крема Унидерм® при местном применении у детей в течение периода, превышающего 6 недель, не изучались.
В связи с тем, что у детей величина соотношения площади поверхности и массы тела больше, чем у взрослых, дети подвержены большему риску подавления функции гипоталамо-гипофизарно-надпочечниковой системы и развития синдрома Кушинга при применении любых ГКС местного действия.
Длительное лечение детей ГКС может привести к нарушениям их роста и развития.
Дети должны получать минимальную дозу препарата, достаточную для достижения эффекта.
У детей от 6 месяцев до 2-х лет курс лечения не должен превышать 5 дней.
Крем для наружного применения 0,1%.
По 15 и 30 г в тубу алюминиевую. Каждую тубу вместе с инструкцией по применению помещают в пачку из картона.
Список Б.
При температуре от 15 до 25°С.
Хранить в недоступном для детей месте.
2 года.
Не использовать после истечения срока годности. Условия отпуска из аптек
По рецепту врача. Производитель. Претензии принимаются по адресу
Открытое акционерное общество «Химико-фармацевтический комбинат «АКРИХИН», 142450, Московская область, Ногинский район, г. Старая Купавна, ул. Кирова, 29.
Mupiderm is a medicated cream. It is used to treat dermal bacterial infection. Mupiderm is a product of Aquatix Pharmaceuticals Limited Lagos, Nigeria but Manufactured by Yash Medicare Pvt. Ltd. India.
 |
| Mupiderm cream |
Composition Of Mupiderm Cream
Mupirocin USP 2% w/w
Water Soluble Ointment base q.s.
Indication Of Mupiderm Cream
Mupiderm is indicated for the topical treatment of the following infections:
Primary skin infection: Impetigo, folliculitis, furunculosis and ecthyma.
Secondary skin infection: Infected dermatitis, infected eczema, infected traumatic lesions e.g., abrasions, insect bites, minor wounds and minor burns.
Prophylaxis: It may be used to avoid bacterial contamination of small wounds, incisions and other clean lesions and to prevent infection of abrasions and small cuts and wounds.
Action
Mupirocin is a new antibiotic produced through fermentation by Pseudomonas fluorescens. Mupirocin inhibits isoleucyl transfer-RNA synthetase, thereby arresting bacterial protein synthesis. Due to this particular mode of action and its unique chemical structure, mupirocin does not show any cross resistance with other clinically available antibiotics.
Mupirocin shows little risk of selection of resistant bacteria if used as prescribed. Mupirocin has bacteriostatic properties at minimum inhibitory concentrations and bactericidal properties at the higher concentrations reached when applied locally. Following intravenous or oral administration, mupirocin is rapidly metabolized to inactive monic acid.
Read Also: All about epiderm cream and lotion
Activity
Mupirocin ointment shows in vivo activity against Staphylococcus aureus (including methicillin-resistant strains), S. Epidermidis and beta-haemolytic Streptococcus species. The in vitro spectrum of activity includes the following bacteria:
Aerobic Gram-positive:
-Staphylococcus aureus (including beta-lactamase producing strains and methicillin resistant strains)
-Staphylococcus epidermidis
-Other coagulase negative Staphylococci (including methicillin resistant strains)
-Streptococcus species.
-Anaerobic Gram-negative:
-Haemophilus Influenzae
-Proteus vulgaris
-Neisseria gonorrhoeae
-Neisseria meningitidis
-Branhamella catarrhalis
-Pasteurella multocida
-Proteus mirabilis
-Enterobacter cloacae
-Enterobacter aerogenes
-Citrobacter freundii
-Bordetella pertussis
Susceptibility: Susceptible to
-Staphylococcus aureus**
-Staphylococcus epidermidis**
-Coagulase-negative staphylococci**
-Streptococcus species
-Neisseria gonorrhoeae
-Neisseria meningitidis
-Moraxella catarrhalis
-Pasteurella multocida
-Haemophilus influenzae
*Clinical efficacy has been demonstrated for susceptible isolates in approved clinical indications.
Range of resistance: 0-23%
Insusceptibility: Insusceptible to Corynebacterium species, enterobacteriaceae, gram negative non-fermenting rods, micrococcus species and Anaerobes.
Cross resistance: Mupirocin does not demonstrate cross resistance with any other known antimicrobial.
Resistance mechanisms: Low-level resistance in staphylococci (MICs 8-256 mcg/ml) has been shown to be due to changes in the native isoleucyl tRNA synthetase enzyme. High level resistance in staphylococci (MICs > 512 mcg/ml) has been shown to be due to a distinct, plasmid encoded isoleucyl tRNA synthetase enzyme. Intrinsic resistance in Gram negative organisms such as the Enterobacteriaceae could be due to poor penetration into the bacterial cell.
Pharmacokinetics
Mupirocin is poorly absorbed through intact human skin. However, if it is absorbed (e.g. through broken/diseased skin) or it is given systemically, it is metabolized to the microbiologically inactive metabolite monic acid by de-esterification which is rapidly excreted in urine. Mupirocin is rapidly eliminated from the body by metabolism to its inactive metabolite monic acid which is excreted mainly by the kidney (90%). It is 95% -97% bound to plasma proteins.
Contraindications
Mupirocin is usually well tolerated but local reactions such as burning, stinging and itching may occur after the application of Mupirocin to the skin. Care is also required in patients with renal impairment.
Read Also: How to prepare and use shaving powder to remove hair
Mupirocin ointment should not be used on patients with a history of hypersensitivity to any of its constituents.
Special Warnings And Special Precautions
For patients with renal impairment: No restrictions unless the condition being treated could lead to absorption of polyethylene glycol and there is evidence of moderate or severe renal impairment. Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys.
In common with other polyethylene glycol-based ointments, mupirocin ointment should not be used in conditions where absorption of large quantities of polyethylene glycol is possible; the excretion of polyethylene glycol may be impaired and could lead to nephrotoxicity and severe metabolic disturbances.
This mupirocin ointment formulation is not suitable for:
-Ophthalmic use
-Intranasal use (in neonates or infants).
-Use in conjunction with cannulae.
-At the site of central venous cannulation.
For intranasal use, a separate presentation, mupirocin nasal, is available. Avoid contact with eyes. If contaminated, the eyes should be thoroughly irrigated with water, until the ointment residues have been removed.
As with other antibacterial products, prolonged use may result in overgrowth of non-susceptible organisms, such as fungi. Treatment with Mupirocin should be avoided, if sensitivity or chemical reaction occurs with the use. Appropriate secondary therapy for the infection must be initiated.
Drug Interactions
No drug interactions have been reported.
Use In Pregnancy And Lactation
Adequate human data on use during pregnancy are not available. However, animal studies have not identified any risk to pregnancy or embryo-fetal development. This drug should be used during pregnancy only if clearly needed.
Adequate human and animal data on use during lactation are not available. It is not known whether this drug is excreted in human milk. Caution should be exercised while administering to a nursing woman.
Read Also: Difference between mycoten vaginal cream and mycoten medicated body cream
Adverse Effects Of Mupiderm
Headache, nausea, burning, stinging, pain, pruritus, rash, cellulitis, dry skin, erythema, pain or bleeding secondary to eczema, secondary wound infection, swelling, tenderness and urticaria are some of the adverse reactions which may occur occasionally with use.
Immune system disorders:
Very rare: Systemic allergic reactions have been reported with mupirocin ointment.
Skin and subcutaneous system disorders:
Common: Burning localized to the area of application.
Uncommon: Itching, erythema, stinging and dryness localized to the area of application.
Uncommon: Cutaneous sensitization reactions to mupirocin or the ointment base.
Overdosage
Application of too much Mupirocin ointment is unlikely to cause any serious problems.
Mupirocin ointment contains polyethylene glycol, which could cause problems in case of overdose in rare cases.
However, if a significant amount is absorbed, which might happen with severe burns or large open wounds, polyethylene toxicity could result, especially in people with kidney problems.
- Overview
- Uses
- Side-effects
- Precautions
- Interactions
- Contraindications
Overview
Mupiderm Ointment is used for Skin infection caused by bacteria, Wounds, Impetigo and other conditions. Mupiderm Ointment may also be used for purposes not listed in this medication guide.
Mupiderm Ointment contains Mupirocin as an active ingredient.
Mupiderm Ointment works by stopping the growth of certain bacteria by blocking the protein synthesis.
Detailed information related to Mupiderm Ointment’s uses, composition, dosage, side effects and reviews is listed below.
Uses
Mupiderm Ointment is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
- Skin infection caused by bacteria
- Wounds
- Impetigo
- Mupiderm Ointment may also be used for purposes not listed here.
Side-effects
The following is a list of possible side-effects that may occur from all constituting ingredients of Mupiderm Ointment. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
- Reddening of the skin
- Rash of round, red welts on the skin
- Swelling of eyes, lips
- Severe skin reactions or allergies
- Severe itching of the skin
- Rash
- Burning sensation
- Dryness
- Localised to the area of application
- Mupiderm Ointment may also cause side-effects not listed here.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
Precautions
Before using Mupiderm Ointment, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
- Extensive burns and open wounds
- Should not consumed by patients having renal impairment
- do not take by mouth. Consult with your doctor before using this medicine on open wounds, dry, chapped, irritated, or sun-burned skin.
- wash your hands before and after applying Mupiderm Ointment. Clean and dry the skin area to be treated.
- do not wash the treated area after immediately applying Mupiderm Ointment. Also avoid the use of other products on the treated area unless directed by your doctor.
- applying an excessive amount may result in pilling. Use a thinner layer or lesser quantity of medicine to avoid pilling.
- avoid getting this medication in your eyes or nose or mouth.
Interactions with Mupiderm Ointment
Please consult your physician or pharmacist or product package for this information.
When not to use Mupiderm Ointment
Composition and Active Ingredients
Mupiderm Ointment is composed of the following active ingredients (salts)
- Mupirocin — 2%W/W
Please note that this medicine may be available in various strengths for each active ingredient listed above.
Packages and Strengths
Please consult your physician or pharmacist or product package for this information.
Frequently asked Questions
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Is Mupiderm Ointment safe to use when pregnant?
No
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Is Mupiderm Ointment safe while breastfeeding?
No
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Can Mupiderm Ointment be used for skin infection caused by bacteria and wounds?
Yes, skin infection caused by bacteria and wounds are among the most common reported uses for Mupiderm Ointment. Please do not use Mupiderm Ointment for skin infection caused by bacteria and wounds without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Mupiderm Ointment.
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Should I use Mupiderm Ointment empty stomach, before food or after food?
TabletWise.com website users have most commonly reported using Mupiderm Ointment after food. However, this may not be reflective of how you should use this medicine. Please follow your doctor’s advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Mupiderm Ointment.
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Is it safe to drive or operate heavy machinery when using this product?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Mupiderm Ointment medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Mupiderm Ointment. Always consult with your doctor for recommendations specific to your body and health conditions.
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Is this medicine or product addictive or habit forming?
Most medicines don’t come with a potential for addiction or abuse. Usually, the government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.
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Can i stop using this product immediately or do I have to slowly wean off the use?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.
Other important Information on Mupiderm Ointment
Missing a dose
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
Overdosage of Mupiderm Ointment
- Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Mupiderm Ointment, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
- Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
- Please consult your physician or pharmacist or product package for more information.
Storage of Mupiderm Ointment
- Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
- Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Mupiderm Ointment.
Expired Mupiderm Ointment
- Taking a single dose of expired Mupiderm Ointment is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
Dosage Information
Please consult your physician or pharmacist or refer to the product package.
Cite this page
Page URL
HTML Link
APA Style Citation
- Mupiderm Ointment — Product — TabletWise.com. (n.d.). Retrieved November 05, 2023, from https://www.tabletwise.com/nigeria/mupiderm-ointment
MLA Style Citation
- «Mupiderm Ointment — Product — TabletWise.com» Tabletwise.com. N.p., n.d. Web. 05 Nov. 2023.
Chicago Style Citation
- «Mupiderm Ointment — Product — TabletWise.com» Tabletwise. Accessed November 05, 2023. https://www.tabletwise.com/nigeria/mupiderm-ointment.
Last updated date
This page was last updated on 9/27/2020.
This page provides information for Mupiderm Ointment Product in English.
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